miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2
نویسندگان
چکیده
MicroRNAs (miRNAs) dysregulation is tightly related to diseases including tumor, neuro disease and cardiovascular disease. In this study, we investigated the potential biological effects of miR-34a its target CXCR3 in phenotypic modulation vascular smooth muscle cells (VSMCs) intracranial aneurysms (IAs). MiR-34a was found be down-regulated IAs patients tested by Real-time PCR decreased GEO data. Meanwhile, our study also showed inhibited matrix metalloproteinases (MMPs) migration VSMCs. Besides, a direct identified via luciferase assay. inhibitory effect on SM-MHC, SM22 while promoted MMPs expression, cell proliferation reversed addition, MMP-2 competitive endogenous RNA (ceRNA) sharing common target. increased level through regulation sponging miR-34a. conclusion, that regulates targets.
منابع مشابه
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ژورنال
عنوان ژورنال: Genetics and Molecular Biology
سال: 2021
ISSN: ['1415-4757', '1678-4685']
DOI: https://doi.org/10.1590/1678-4685-gmb-2020-0124